Article
Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia.
American journal of medical genetics - 15 Mar 1994
Coon H, Sobell J, Heston L, Sommer S, Hoff M, Holik J, Umar F, Robertson M, Reimherr F, Wender P
Abstract excerpt
As alterations in GABAergic neurotransmission have been indirectly implicated in the pathogenetics of schizophrenia, GABAA receptor subunit genes are plausible candidate genes for the illness. We undertook a search for sequence variations in the coding region of beta 1 subunit gene by designing i...
Topics
- Adolescent
- Aged
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA Mutational Analysis
- DNA Primers
- Exons
- Female
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Nucleic Acid Conformation
- Pedigree
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic