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Article

Screening schizophrenic patients for mutations in the amyloid precursor protein gene.

Psychiatric genetics - 1 Jan 1994

Morris S, Leung J, Sharp C, Blackwood D, Muir W, St Clair D

Abstract excerpt

A limited number of rare missense mutations in exons 16 and 17 of the amyloid precursor protein (APP) gene have been reported. They are associated with a variety of phenotypes including cerebral haemorrhage, multi-infarct dementia and Alzheimer's disease. We recently reported an alanine to valine mutation in codon 713 in a single case of chronic familial schizophrenia with cognitive deficits. Using denaturing...

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Source

Identifiers

PMID: 8049900
DOI: 10.1097/00041444-199421000-00004

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening schizophrenic patients for mutations in the amyloid precursor protein gene.PMID 8049900Read ↗

Screening Alzheimer's disease patients for mutations in the amyloid precursor protein gene.Semantic proximity Read ↗

Amyloid precursor protein mutation at codon 713 (Ala-->Val) does not cause schizophrenia: non-pathogenic variant found at codon 705 (silent).Semantic proximity Read ↗

Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease.Semantic proximity Read ↗

Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.Semantic proximity Read ↗

Screening for the APP codon 670/671 mutations in Alzheimer's disease.Semantic proximity Read ↗

Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence.Semantic proximity Read ↗

C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families.Semantic proximity Read ↗

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.Semantic proximity Read ↗

A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases.Semantic proximity Read ↗

A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene.Semantic proximity Read ↗

Screening for mutations at codon 717 of the amyloid precursor protein gene in Alzheimer's disease.Semantic proximity Read ↗

Absence of APP713 mutation in Italian and Russian families with schizophrenia.Semantic proximity Read ↗

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