Article
Attenuation phenotype of a cell culture-adapted variant of hepatitis A virus (HM175/p16) in susceptible New World owl monkeys.
The Journal of infectious diseases - 1 Sept 1993
Taylor K L, Murphy P C, Asher L V, LeDuc J W, Lemon S M
Abstract excerpt
The virulence of a clonally isolated, cell culture-adapted hepatitis A virus (HM175/p16) was assessed in 4 seronegative owl monkeys inoculated intravenously with 2.8 x 10(4) radioimmunofocus-forming units of virus. The virus was highly attenuated, even though its complete nucleotide sequence cont...
Topics
- Adaptation, Biological
- Alanine Transaminase
- Animals
- Antibody Formation
- Aotidae
- Disease Susceptibility
- Female
- Genetic Variation
- Hepatitis A
- Hepatovirus
- Liver
- Male
- Mutation
- Phenotype
- Serial Passage
- Splenectomy
- Time Factors
- Viremia