Article
In vivo replication and reversion to wild type of a neutralization-resistant antigenic variant of hepatitis A virus.
The Journal of infectious diseases - 1 Jan 1990
Lemon S M, Binn L N, Marchwicki R, Murphy P C, Ping L H, Jansen R W, Asher L V, Stapleton J T, Taylor D G, LeDuc J W
Abstract excerpt
Six seronegative owl monkeys were intravenously inoculated with an antigenic variant (S18) of hepatitis A virus that is highly adapted to growth in cell culture and resists neutralization by monoclonal antibodies due to replacement of aspartic acid 70 of capsid protein VP3 with histidine. Each developed hepatitis 22-33 days after inoculation. Virus in feces, serum, and liver was quantified by radioimmunofocus...
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