Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination.

doi:10.1128/JVI.65.4.2056-2065.1991

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Article

Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination.

Journal of virology - 1 Apr 1991

Lemon S M, Murphy P C, Shields P A, Ping L H, Feinstone S M, Cromeans T, Jansen R W

Abstract excerpt

Variants of hepatitis A virus (pHM175 virus) recovered from persistently infected green monkey kidney (BS-C-1) cells induced a cytopathic effect during serial passage in BS-C-1 or fetal rhesus kidney (FRhK-4) cells. Epitope-specific radioimmunofocus assays showed that this virus comprised two vir...

Topics

Animals
Antigenic Variation
Antigens, Viral
Base Sequence
Capsid
Cells, Cultured
Chromosome Mapping
Cytopathogenic Effect, Viral
Epitopes
Hepatitis A
Hepatitis A Antigens
Hepatovirus
Macaca
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neutralization Tests

Phenotype

Recombination, Genetic

Source

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Identifiers

PMID: 1705995
DOI: 10.1128/JVI.65.4.2056-2065.1991
PMCID: PMC240056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1705995-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.