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Article

The French neurotropic vaccine strain of yellow fever virus accumulates mutations slowly during passage in cell culture.

Virus research - 1 Aug 2000

Holbrook M R, Li L, Suderman M T, Wang H, Barrett A D

Abstract excerpt

This study of the yellow fever French neurotropic vaccine strain from the Institut Pasteur (FNV-IP) demonstrates that this viral genome is not as stable as that of the 17D-204 vaccine virus. FNV-IP was plaque-purified three times and then passaged eight times in Vero cells. Viral populations from the second and eighth passage post purification were sequenced and compared to the published sequences of FNV-IP. The...

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Source

Identifiers

PMID: 10989183
DOI: 10.1016/s0168-1702(00)00168-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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