Article
Nucleotide sequence of wild-type hepatitis A virus GBM in comparison with two cell culture-adapted variants.
Journal of virology - 1 Jan 1994
Graff J, Normann A, Feinstone S M, Flehmig B
Abstract excerpt
In order to study cell tropism and attenuation of hepatitis A virus (HAV), the genome of HAV wild-type GBM and two cell culture-adapted variants, GBM/FRhK and GBM/HFS, were cloned and sequenced after amplification by reverse transcriptase-PCR. During virus cultivation, the HAV variant GBM/FRhK ha...
Topics
- Adaptation, Biological
- Animals
- Capsid
- Capsid Proteins
- Cells, Cultured
- Cloning, Molecular
- Genetic Variation
- Genome, Viral
- Hepatovirus
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- RNA, Viral
- Sequence Analysis, DNA
- Sequence Deletion
- Sequence Homology, Nucleic Acid
- Species Specificity