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Article

Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-1 cells.

Journal of virology - 1 Nov 1992

Day S P, Murphy P, Brown E A, Lemon S M

Abstract excerpt

Passage of human hepatitis A virus (HAV) in cell culture results in attenuation of the virus as well as progressive increases in the efficiency of virus replication in cell culture. Because the presence of identical mutations within the 5' nontranslated regions (5'NTRs) of several independently isolated cell culture-adapted HAV variants suggests that the 5'NTR may play a role in determining this change in virus...

Topics

Animals
Antigens, Viral
Base Sequence
Cells, Cultured
DNA Mutational Analysis
DNA, Recombinant
Haplorhini
Hepatitis A
Kidney
Molecular Sequence Data
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Viral

Regulatory Sequences, Nucleic Acid

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1404601
DOI: 10.1128/JVI.66.11.6533-6540.1992
PMCID: PMC240147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404601-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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