Article
Allelotype of head and neck paragangliomas: allelic imbalance is confined to the long arm of chromosome 11, the site of the predisposing locus PGL.
Genes, chromosomes & cancer - 1 Oct 1994
Devilee P, van Schothorst E M, Bardoel A F, Bonsing B, Kuipers-Dijkshoorn N, James M R, Fleuren G, van der Mey A G, Cornelisse C J
Abstract excerpt
Paragangliomas of the head and neck region are usually slow growing, benign tumors. A considerable fraction has a positive family history, and the predisposing locus, PGL, has recently been assigned to 11q22-q23. The inheritance pattern of the disease suggests that PGL undergoes maternal genomic imprinting. We have investigated 26 tumor samples from 22 patients with head and neck paragangliomas for the occurrence...
Topics
- Alleles
- Chromosomes, Human, Pair 11
- DNA Probes
- Female
- Flow Cytometry
- Genomic Imprinting
- Head and Neck Neoplasms
- Humans
- Paraganglioma, Extra-Adrenal
- Polymerase Chain Reaction