Article
Comprehensive analysis of chromosome 1p deletions in neuroblastoma.
Medical and pediatric oncology - 1 Jan 2001
Maris J M, Guo C, Blake D, White P S, Hogarty M D, Thompson P M, Rajalingam V, Gerbing R, Stram D O, Matthay K K, Seeger R C, Brodeur G M
Abstract excerpt
BACKGROUND: Chromosome 1p deletions are common in advanced neuroblastomas, but the biological and clinical implications of this clonal rearrangement remain controversial. Previous studies of chromosome 1p loss of heterozygosity (LOH) have been limited by analyses of relatively small number of tumors derived from heterogeneously assessed and treated patient populations. Therefore, a strictly representative cohort...
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