Article
Molecular screening of pituitary adenomas for gene mutations and rearrangements.
The Journal of clinical endocrinology and metabolism - 1 Jul 1993
Herman V, Drazin N Z, Gonsky R, Melmed S
Abstract excerpt
Although pituitary tumors arise as benign monoclonal neoplasms, genetic alterations have not readily been identified in these adenomas. We studied restriction fragment abnormalities involving the GH gene locus, and mutations in the p53 and H-, K- and N-ras genes in 22 human GH cell adenomas. Twen...
Topics
- Adenoma
- Base Sequence
- Chromosomes, Human, Pair 11
- DNA, Neoplasm
- Gene Deletion
- Gene Rearrangement
- Genes, p53
- Genes, ras
- Growth Hormone
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Pituitary Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Prolactinoma