Article
Ras mutations in human pituitary tumors.
The Journal of clinical endocrinology and metabolism - 1 Apr 1992
Karga H J, Alexander J M, Hedley-Whyte E T, Klibanski A, Jameson J L
Abstract excerpt
The cellular basis for pituitary neoplasia is poorly understood. Mutations that activate the ras protooncogenes have been identified in a number of different types of human cancers and potentially represent one of the genetic alterations that occur in pituitary tumors. In this study we examined 19 pituitary tumors for the occurrence of ras mutations. The tumor types included 11 nonfunctioning adenomas, 6...
Topics
- Adenoma
- Adrenocorticotropic Hormone
- Adult
- Aged
- DNA, Neoplasm
- Female
- Follicle Stimulating Hormone
- Genes, ras
- Humans
- Immunohistochemistry
- Luteinizing Hormone
- Male