Article
Molecular genetic studies of sporadic pituitary tumors.
The Journal of clinical endocrinology and metabolism - 1 Feb 1994
Boggild M D, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTernan P, Perrett C W, Thakker R V, Clayton R N
Abstract excerpt
Tumor formation may result from the activation of dominant oncogenes or by inactivation of recessive, tumor suppressor genes. The role of such mutations in the development of pituitary tumors has been studied. Tumors from 88 patients, representing the 4 major classes of adenoma, were investigated. In DNA extracted from matched leukocyte and tumor samples, allelic deletions were sought with 15 probes identifying...
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