Expression of P-glycoprotein-mediated drug resistance in CHO cells surviving a single X-ray dose of 30 Gy.

doi:10.1080/09553009314552171

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Article

Expression of P-glycoprotein-mediated drug resistance in CHO cells surviving a single X-ray dose of 30 Gy.

International journal of radiation biology - 1 Jun 1993

McClean S, Hosking L K, Hill B T

Abstract excerpt

We reported previously that Chinese hamster ovary (CHO) cells surviving exposure to repeated doses of 9 Gy of X-irradiation in vitro expressed a multiple drug resistance phenotype characterized by cross-resistance to epipodophyllotoxins and to Vinca alkaloids, and by P-glycoprotein (Pgp) overexpr...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
CHO Cells
Carrier Proteins
Cell Survival
Cricetinae
Drug Resistance
Gene Expression
Membrane Glycoproteins
Phenotype
Radiation Genetics

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