Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic coping mechanisms observed in Leishmania tropica, from the Middle East region, enhance the survival of the parasite after drug exposure.

PloS one - 1 Jan 2024

Glans Hedvig, Matos Gabriel M, Bradley Maria, Downing Tim, Andersson Björn

Abstract excerpt

INTRODUCTION: Cutaneous leishmaniasis caused by L. tropica is common in the Middle East and treatment failure and drug resistance are known to occur. Several genetic mechanisms: aneuploidy, recombination and loss of heterozygosity, single nucleotide polymorphism (SNP) changes, copy number variation (CNV), and mutation of the H locus associated with drug resistance have been described. MATERIALS AND METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiprotozoal Agents
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Leishmaniasis, Cutaneous

Share to Middle East

Share to Phylogeny

Source

Open in PubMed Open full text

Identifiers

PMID: 39625894
DOI: 10.1371/journal.pone.0310821
PMCID: PMC11614225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic coping mechanisms observed in Leishmania tropica, from the Middle East region, enhance the survival of the parasite after drug exposure.PMID 39625894Read ↗

Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapiesSemantic proximity Read ↗

Insights on genomic profiles of drug resistance and virulence in a cohort of <i>Leishmania infantum</i> isolates from the Mediterranean areaSemantic proximity Read ↗

High genome plasticity and frequent genetic exchange in <i>Leishmania tropica</i> isolates from Afghanistan, Iran and SyriaSemantic proximity Read ↗

High genome plasticity and frequent genetic exchange in Leishmania tropica isolates from Afghanistan, Iran and Syria.Semantic proximity Read ↗

Expanded genome-wide comparisons give novel insights into population structure and genetic heterogeneity of Leishmania tropica complex.Semantic proximity Read ↗

Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions.Semantic proximity Read ↗

Epidemiological Insights: Unraveling Drug Resistance in Leishmania Species through Comprehensive StudiesSemantic proximity Read ↗

(Post-) Genomic approaches to tackle drug resistance in Leishmania.Semantic proximity Read ↗

Insights into Genetic Heterogeneity and Drug Resistance in Leishmania donovani of the Indian sub-continent from genomic dataSemantic proximity Read ↗

Genomic insights into virulence mechanisms of Leishmania donovani: evidence from an atypical strain.Semantic proximity Read ↗

Gene Expression in <i>Leishmania</i> Is Regulated Predominantly by Gene DosageSemantic proximity Read ↗

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy numberSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.