Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.

Article

Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.

Cancer research - 1 Aug 1991

Takano H, Kohno K, Ono M, Uchida Y, Kuwano M

Abstract excerpt

We have isolated two etoposide (VP16)-resistant cell lines, KB/VP-1 and KB/VP-2, from human cancer KB cells after stepwise exposure to increasing doses of VP16. KB/VP-1 and KB/VP-2 showed 30- and 50-fold higher resistance to VP16 and also 20- and 30-fold higher resistance to teniposide than the p...

Topics

Carcinoma, Squamous Cell
DNA
DNA Topoisomerases, Type II
Etoposide
Humans
KB Cells
Mutation
Neoplasms
Phosphorylation
Tumor Cells, Cultured

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