Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zidovudine susceptibility testing of human immunodeficiency virus type 1 (HIV) clinical isolates.

Journal of virological methods - 1 Mar 1993

Shafer R W, Kozal M J, Katzenstein D A, Lipil W H, Johnstone I F, Merigan T C

Abstract excerpt

Traditional antiviral susceptibility testing methods using cell lines can be applied to no more than about 30% of clinical HIV isolates (Larder et al., 1989a; Fenyo et al., 1989). We tested the cell-free supernatant from low passage clinical HIV isolates using donor peripheral blood mononuclear cells (PBMC). Drug susceptibility was assessed by measuring the effect of increasing zidovudine (ZDV) concentrations on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV-1
Share to Base Sequence
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Genes, Viral

Share to Microbial Sensitivity Tests

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8097199
DOI: 10.1016/0166-0934(93)90019-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zidovudine susceptibility testing of human immunodeficiency virus type 1 (HIV) clinical isolates.PMID 8097199Read ↗

Susceptibility of HIV-1 isolates to zidovudine: correlation between widely applicable culture test and PCR analysis.Semantic proximity Read ↗

Comparison of culture- and non-culture-based methods for quantification of viral load and resistance to antiretroviral drugs in patients given zidovudine monotherapy.Semantic proximity Read ↗

Characterization of HIV isolates arising after prolonged zidovudine therapy.Semantic proximity Read ↗

Natural resistance of human immunodeficiency virus type 2 to zidovudine.Semantic proximity Read ↗

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay.Semantic proximity Read ↗

Zidovudine-resistant and -sensitive HIV-1 isolates from patients on drug therapy: in vitro studies evaluating level of replication-competent viruses and cytopathogenicity.Semantic proximity Read ↗

Standardized peripheral blood mononuclear cell culture assay for zidovudine susceptibility testing of clinical human immunodeficiency virus type 1 isolates: effect of reducing the numbers of replicates and concentrations.Semantic proximity Read ↗

Rapid phenotypic drug susceptibility assay for HIV-1 with a CCR5 expressing indicator cell line.Semantic proximity Read ↗

Natural variation of drug susceptibility in wild-type human immunodeficiency virus type 1.Semantic proximity Read ↗

HIV-1 sensitivity to zidovudine: a consensus culture technique validated by genotypic analysis of the reverse transcriptase.Semantic proximity Read ↗

The role of HIV type 1 phenotype and genotype in long-term responders to zidovudine therapy.Semantic proximity Read ↗

pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.