Article
Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay.
Antimicrobial agents and chemotherapy - 1 Mar 1990
Larder B A, Chesebro B, Richman D D
Abstract excerpt
Conventional assays based on infection of T-cell lymphoblastoid lines with tissue culture-adapted strains of human immunodeficiency virus (HIV) are well established and have been used successfully to discover potent inhibitors of HIV replication. In this report we show that such assays are not ea...
Topics
- Antiviral Agents
- Coloring Agents
- Drug Resistance, Microbial
- Genetic Variation
- HIV-1
- HIV-2
- HeLa Cells
- Humans
- Microbial Sensitivity Tests
- Viral Plaque Assay
- Zidovudine