Article
Zidovudine-resistant and -sensitive HIV-1 isolates from patients on drug therapy: in vitro studies evaluating level of replication-competent viruses and cytopathogenicity.
AIDS (London, England) - 1 Dec 1992
Tremblay M, Rooke R, Wainberg M A
Abstract excerpt
OBJECTIVE: To compare biological properties of zidovudine-resistant variants of HIV-1 isolated from subjects on long-term drug therapy with drug-sensitive parental isolates obtained from the same patients before initiation of treatment. METHODS: Clinical HIV-1 strains were isolated following co-incubation of patient peripheral blood mononuclear cells with mitogen-stimulated umbilical cord blood lymphocytes. Drug...
Topics
- Acquired Immunodeficiency Syndrome
- Cell Survival
- Cytopathogenic Effect, Viral
- Drug Resistance, Microbial
- Genetic Variation
- HIV Core Protein p24
- HIV-1
- Humans
- Phenotype
- Selection, Genetic