Article
Detection of P-glycoprotein in squamous cell carcinomas of the head and neck.
Archives of otolaryngology--head & neck surgery - 1 Apr 1993
Kelley D J, Pavelic Z P, Gapany M, Stambrook P, Pavelic L, Gapany S, Gluckman J L
Abstract excerpt
One established mechanism of multidrug resistance is elevated expression of P-glycoprotein. The expression of P-glycoprotein by immunohistochemistry was examined in squamous cell carcinomas of the head and neck using a newly developed monoclonal antibody, UIC2, which is specific to the human MDR1 gene product and recognizes an external epitope of the protein. P-glycoprotein was detected in 60% of the samples....
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