Article
Detection of P-glycoprotein in squamous cell carcinomas of the head and neck.
Archives of otolaryngology--head & neck surgery - 1 Apr 1993
Kelley D J, Pavelic Z P, Gapany M, Stambrook P, Pavelic L, Gapany S, Gluckman J L
Abstract excerpt
One established mechanism of multidrug resistance is elevated expression of P-glycoprotein. The expression of P-glycoprotein by immunohistochemistry was examined in squamous cell carcinomas of the head and neck using a newly developed monoclonal antibody, UIC2, which is specific to the human MDR1...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibodies, Monoclonal
- Antineoplastic Combined Chemotherapy Protocols
- Biopsy
- Carcinoma, Squamous Cell
- Cell Differentiation
- Drug Resistance
- Evaluation Studies as Topic
- Gene Expression
- Head and Neck Neoplasms
- Hospitals, University
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Membrane Glycoproteins
- Neoplasm Staging
- Ohio
- Phenotype