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Article

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1 Jan 1990

Abstract excerpt

P-glycoprotein is a highly conserved membrane protein shown to be overexpressed in many multidrug-resistant tumor cell lines. P-glycoprotein is encoded by a small gene family in mammalian cells. Class I and II isoforms cause multidrug resistance, whereas class III does not. In this report, we have characterized three P-glycoprotein-specific monoclonal antibodies (mAbs) by high-resolution epitope mapping with a...

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PMID: 1688652
DOI: 10.1073/pnas.87.1.152

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