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Article

Expression of P-glycoprotein in epithelial ovarian cancer: evaluation as a marker of multidrug resistance.

American journal of obstetrics and gynecology - 1 Jul 1990

Rubin S C, Finstad C L, Hoskins W J, Saigo P E, Provencher D M, Federici M G, Hakes T B, Markman M, Reichman B S, Lloyd K O

Abstract excerpt

The multidrug-resistance gene, MDR1, encodes a plasma membrane glycoprotein termed P-glycoprotein that mediates active cellular efflux of certain chemotherapeutic agents. P-Glycoprotein expression was evaluated in 98 frozen tumor specimens from 57 patients with epithelial ovarian cancer by the indirect immunoperoxidase technique with monoclonal antibodies C219 and JSB-1 used for detection. Tumor specimens were...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antibodies, Monoclonal
Antigens, Neoplasm
Drug Resistance
Drug Screening Assays, Antitumor
Female
Humans
Membrane Glycoproteins
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Ovarian Neoplasms

Phenotype

Proteins

Source

Identifiers

PMID: 1973872
DOI: 10.1016/s0002-9378(11)90670-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1973872-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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