Article
Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma.
Journal of the National Cancer Institute - 16 Jan 1991
Verrelle P, Meissonnier F, Fonck Y, Feillel V, Dionet C, Kwiatkowski F, Plagne R, Chassagne J
Abstract excerpt
In 20 women with breast carcinoma, 17 of whom had locally advanced cancer and 3 of whom had confirmed metastases, the expression of P-glycoprotein was evaluated before the start of a chemotherapy regimen that included multidrug resistance-related drugs. With the use of the C494 monoclonal antibody in an avidin-biotin-immunoperoxidase technique, P-glycoprotein was detected in 17 of 20 tumor samples. Results were...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adult
- Aged
- Antibodies, Monoclonal
- Breast Neoplasms
- Carcinoma
- Drug Resistance
- Female
- Humans
- Immunohistochemistry