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Article

Rapid prediction of rifampin susceptibility of Mycobacterium tuberculosis.

American journal of respiratory and critical care medicine - 1 Jun 1997

Ohno H, Koga H, Kuroita T, Tomono K, Ogawa K, Yanagihara K, Yamamoto Y, Miyamoto J, Tashiro T, Kohno S

Abstract excerpt

We evaluated the relationship between rifampin (RIF) susceptiblility and amino acid substitution in rpoB gene of Mycobacterium tuberculosis and the usefulness of rpoB gene sequencing in the rapid prediction of RIF susceptibility of M. tuberculosis in clinical specimens. A total of 76 genetic alterations in the 69 bp core region of rpoB gene were detected in 74 of 130 M. tuberculosis strains. Examination of the...

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PMID: 9196115
DOI: 10.1164/ajrccm.155.6.9196115

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Rapid prediction of rifampin susceptibility of Mycobacterium tuberculosis.PMID 9196115Read ↗

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