Article
Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.
The New England journal of medicine - 29 Mar 1990
Leppert M, Burt R, Hughes J P, Samowitz W, Nakamura Y, Woodward S, Gardner E, Lalouel J M, White R
Abstract excerpt
We studied a large kindred with a history of colorectal cancer of early onset. Proctosigmoidoscopic examination of 51 family members identified only 2 with familial polyposis coli, which strongly predisposes those who have it to colorectal cancer and which is defined as the presence of more than...
Topics
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Chromosomes, Human, Pair 5
- Colonic Neoplasms
- Colorectal Neoplasms
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Lod Score
- Male
- Middle Aged
- Mutation