Article
Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.
The New England journal of medicine - 29 Mar 1990
Leppert M, Burt R, Hughes J P, Samowitz W, Nakamura Y, Woodward S, Gardner E, Lalouel J M, White R
Abstract excerpt
We studied a large kindred with a history of colorectal cancer of early onset. Proctosigmoidoscopic examination of 51 family members identified only 2 with familial polyposis coli, which strongly predisposes those who have it to colorectal cancer and which is defined as the presence of more than 100 polyps in the colon. However, eight family members had 2 to 40 colonic polyps. We suspected that in this family,...
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