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Article

Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.

American journal of human genetics - 1 Jul 1992

Spirio L, Otterud B, Stauffer D, Lynch H, Lynch P, Watson P, Lanspa S, Smyrk T, Cavalieri J, Howard L

Abstract excerpt

Adenomatous polyps are an intermediate in the pathway to colon carcinoma. An inherited disorder, familial adenomatous polyposis coli (APC), is characterized by hundreds to thousands of adenomatous polyps. A previously reported family had colon cancer associated with a low average but highly heterogenous number of colonic polyps, this phenotype mapped to the APC locus on 5q. Four new families have been ascertained...

Topics

Adenomatous Polyposis Coli
Adolescent
Adult
Aged
Chromosome Mapping
Colonic Neoplasms
Female
Genetic Variation
Humans
Lod Score
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pedigree

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 1319115
PMCID: PMC1682871

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1319115-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.PMID 1319115Read ↗

Alleles of the APC gene: an attenuated form of familial polyposis.Semantic proximity Read ↗

Genetic characterization of the APC locus involved in familial adenomatous polyposis.Semantic proximity Read ↗

Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP)Semantic proximity Read ↗

Attenuated Familial Adenomatous PolyposisSemantic proximity Read ↗

Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.Semantic proximity Read ↗

American founder mutation for attenuated familial adenomatous polyposis.Semantic proximity Read ↗

[Familial adenomatous polyposis].Semantic proximity Read ↗

Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis.Semantic proximity Read ↗

Attenuated Familial Adenomatous Polyposis: A Phenotypic Diagnosis but Obsolete Term?Semantic proximity Read ↗

Colon polyps: a damaged developmental system and a precursor to cancer.Semantic proximity Read ↗

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.Semantic proximity Read ↗

A CA-repeat polymorphism close to the adenomatous polyposis coli (APC) gene offers improved diagnostic testing for familial APC.Semantic proximity Read ↗

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