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Article

Identification and characterization of the familial adenomatous polyposis coli gene.

Cell - 9 Aug 1991

Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M

Abstract excerpt

DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb region deleted in two of the patients. The intron-exon boundary sequences were defined for each of these genes, and single-strand conformation polymorphism analysis of exons from DP2.5 identified four mutations specific to APC patients. Each of two aberrant...

Topics

Adenomatous Polyposis Coli
Amino Acid Sequence
Base Sequence
Chromosome Deletion
DNA
Exons
Genes
Humans
Molecular Sequence Data
Mutation
Oligonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Polymerase Chain Reaction

Polymorphism, Genetic

Restriction Mapping

Source

Identifiers

PMID: 1651174
DOI: 10.1016/0092-8674(81)90021-0

Genes

APC
SRP19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1651174-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification and characterization of the familial adenomatous polyposis coli gene.PMID 1651174Read ↗

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