Article
Improved predictive carrier testing for familial adenomatous polyposis using DNA from a single archival specimen and polymorphic markers with multiple alleles.
Human pathology - 1 Dec 1993
Bapat B, Mitri A, Greenberg C R
Abstract excerpt
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition caused by mutations in a candidate tumor suppressor gene, adenomatous polyposis coli. Predictive carrier testing for FAP can be accomplished by DNA linkage or mutation detection analysis. In many FAP families all af...
Topics
- Adenomatous Polyposis Coli
- Adult
- Alleles
- Base Sequence
- Child, Preschool
- DNA, Neoplasm
- Female
- Genes, APC
- Genetic Carrier Screening
- Genetic Linkage
- Humans
- Male
- Molecular Sequence Data
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Factors