Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity.

Molecular and cellular biology - 1 May 2002

Ma Peihong, Magut Maureen, Chen XinBin, Chen Chang-Yan

Abstract excerpt

The tumor suppressor p53 eliminates cancer-prone cells via multiple mechanisms, including apoptosis. Ras elicits apoptosis in cells after protein kinase C (PKC) downregulation. However, the role of p53 in Ras-mediated apoptosis has not been fully investigated. Here, we demonstrate that mouse fibroblasts that express wild-type p53 are more susceptible to apoptosis elicited by PKC inhibition if Ras is transiently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to Cell Survival
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Oligonucleotides, Antisense

Share to Protein Kinase C

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 11940651
DOI: 10.1128/MCB.22.9.2928-2938.2002
PMCID: PMC133752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity.PMID 11940651Read ↗

Roles of PKC isoforms in the induction of apoptosis elicited by aberrant Ras.Semantic proximity Read ↗

Differential regulation of p21 by p53 and Rb in cellular response to oxidative stressSemantic proximity Read ↗

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic RasSemantic proximity Read ↗

Tumor suppressor p53 is a direct transcriptional activator of the human bax geneSemantic proximity Read ↗

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.Semantic proximity Read ↗

Mediation of c-Myc-Induced Apoptosis by p53Semantic proximity Read ↗

Sensitization of human pancreatic cancer cells harboring mutated K-ras to apoptosis.Semantic proximity Read ↗

Protein kinase C delta is required for survival of cells expressing activated p21RAS.Semantic proximity Read ↗

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.Semantic proximity Read ↗

Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest.Semantic proximity Read ↗

Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis.Semantic proximity Read ↗

Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.