Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing.

doi:10.1016/S1357-4310(97)01017-4

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Article

Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing.

Molecular medicine today - 1 Apr 1997

Gayther S A, Ponder B A

Abstract excerpt

Two cancer susceptibility genes, BRCA1 on chromosome 17q12-21 and BRCA2 on chromosome 13q12-13, are thought to be responsible for approximately 80% of families containing multiple cases of early-onset female breast cancer. Germline mutations of BRCA1 are also associated with ovarian cancer and mu...

Topics

BRCA2 Protein
Female
Genes, BRCA1
Genes, Tumor Suppressor
Genetic Testing
Humans
Male
Mutation
Neoplasm Proteins
Neoplasms
Predictive Value of Tests
Transcription Factors

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