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Article

Germ-line exclusion of a single p53 allele by premature termination of translation in a Li-Fraumeni syndrome family.

Oncogene - 1 Oct 1994

Stolzenberg M C, Brugières L, Gardes M, Dessarps-Freichey F, Chompret A, Bressac B, Lenoir G, Bonaïti-Pellié C, Lemerle J, Feunteun J

Abstract excerpt

Germline p53 mutations have been detected in approximately half of the families affected by the Li-Fraumeni syndrome (LFS), in which they are believed to represent the genetic status predisposing to multiple cancers. Failure to detect mutations in the other half of LFS families suggests that sequence analysis, which has been limited to the p53 gene coding region, have overlooked other genetic events lying outside...

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PMID: 8084585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Germ-line exclusion of a single p53 allele by premature termination of translation in a Li-Fraumeni syndrome family.PMID 8084585Read ↗

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