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Article

Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family.

Human genetics - 1 Jun 1998

Evans S C, Mims B, McMasters K M, Foster C J, deAndrade M, Amos C I, Strong L C, Lozano G

Abstract excerpt

Li-Fraumeni syndrome (LFS) is characterized by a high risk of sarcomas, early onset of breast cancer, and a diversity of other cancers occurring as multiple primary tumors in multiple family members. In many families with LFS, germline mutations within the tumor-suppressor gene p53 have been iden...

Topics

Adult
Alleles
Female
Genes, p53
Genetic Linkage
Germ-Line Mutation
Humans
Li-Fraumeni Syndrome
Male
Mutation
Pedigree
Polymorphism, Single-Stranded Conformational
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9703430
DOI: 10.1007/s004390050761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9703430-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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