Article
Germ-line splicing mutation of the p53 gene in a cancer-prone family.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1992
Warneford S G, Witton L J, Townsend M L, Rowe P B, Reddel R R, Dalla-Pozza L, Symonds G
Abstract excerpt
Li-Fraumeni syndrome is a rare autosomal dominant susceptibility to a variety of cancers including carcinomas of the breast and the adrenal cortex, tumors of brain and muscle tissue, and leukemias. Affected individuals develop cancer at a young age and often at multiple primary sites. A study has been conducted into the genetic basis of cancer in a particular Li-Fraumeni syndrome family. Examination of p53 as a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.