Article
Detection of novel germ-line p53 mutations in diverse-cancer-prone families identified by selecting patients with childhood adrenocortical carcinoma.
Journal of the National Cancer Institute - 6 May 1992
Sameshima Y, Tsunematsu Y, Watanabe S, Tsukamoto T, Kawa-ha K, Hirata Y, Mizoguchi H, Sugimura T, Terada M, Yokota J
Abstract excerpt
BACKGROUND: Germ-line p53 mutations appear to be inherited among the members of families diagnosed with Li-Fraumeni syndrome (LFS). The mutations detected in those families to date have been clustered in exon 7 of the p53 gene and, typically, have been single-base substitutions resulting in amino...
Topics
- Adrenal Cortex Neoplasms
- Amino Acid Sequence
- Base Sequence
- Carcinoma
- DNA Mutational Analysis
- Genes, Dominant
- Genes, p53
- Humans
- Li-Fraumeni Syndrome
- Molecular Sequence Data
- Mutation