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Article

Single base pair germ-line deletion in the p53 gene in a cancer predisposed family.

Human genetics - 1 Jul 1994

Hamelin R, Barichard F, Henry I, Junien C, Thomas G

Abstract excerpt

A family with an aggregation of adrenocortical carcinoma, rhabdomyosarcoma, osteosarcoma, and early onset breast cancer was referred to our laboratory. Because this aggregation was reminiscent of Li-Fraumeni syndrome, germ-line mutation of the p53 tumor suppressor gene was sought in the DNA of two affected members. The highly conserved regions spanning exons 5 to 8 of the p53 gene were screened by a previously...

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Identifiers

PMID: 8034301
DOI: 10.1007/BF02272849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single base pair germ-line deletion in the p53 gene in a cancer predisposed family.PMID 8034301Read ↗

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