Article
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
Science (New York, N.Y.) - 30 Nov 1990
Malkin D, Li F P, Strong L C, Fraumeni J F, Nelson C E, Kim D H, Kassel J, Gryka M A, Bischoff F Z, Tainsky M A
Abstract excerpt
Familial cancer syndromes have helped to define the role of tumor suppressor genes in the development of cancer. The dominantly inherited Li-Fraumeni syndrome (LFS) is of particular interest because of the diversity of childhood and adult tumors that occur in affected individuals. The rarity and high mortality of LFS precluded formal linkage analysis. The alternative approach was to select the most plausible...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Cloning, Molecular
- Codon
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Genes, p53
- Genetic Testing