Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

doi:10.1126/science.1978757

Article

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

Science (New York, N.Y.) - 30 Nov 1990

Malkin D, Li F P, Strong L C, Fraumeni J F, Nelson C E, Kim D H, Kassel J, Gryka M A, Bischoff F Z, Tainsky M A

Abstract excerpt

Familial cancer syndromes have helped to define the role of tumor suppressor genes in the development of cancer. The dominantly inherited Li-Fraumeni syndrome (LFS) is of particular interest because of the diversity of childhood and adult tumors that occur in affected individuals. The rarity and high mortality of LFS precluded formal linkage analysis. The alternative approach was to select the most plausible...

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

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