Article
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
Nature - 1 Jan 2000
Srivastava S, Zou Z Q, Pirollo K, Blattner W, Chang E H
Abstract excerpt
Tumour suppressor genes, whose usual function seems to be controlling normal cell proliferation, have been implicated in many inherited and sporadic forms of malignancies Much evidence supports the concept of tumour formation by loss-of-function mutations in suppressor genes, as predicted by the...
Topics
- Base Sequence
- Codon
- DNA, Neoplasm
- Female
- Fibroblasts
- Genes, p53
- Germ Cells
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Neoplastic Syndromes, Hereditary
- Phenotype