Article
Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.
Journal of virology - 1 Apr 1995
Niewiesk S, Daenke S, Parker C E, Taylor G, Weber J, Nightingale S, Bangham C R
Abstract excerpt
There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human immunodeficiency virus type 1. In the present study, we investigated whether naturall...
Topics
- Amino Acid Sequence
- Epitopes
- Gene Products, tax
- Genes, fos
- Genetic Variation
- HLA-A2 Antigen
- Human T-lymphotropic virus 1
- Humans
- Molecular Sequence Data
- Promoter Regions, Genetic
- T-Lymphocytes, Cytotoxic
- Transcriptional Activation