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Article

Evolution of the hepatitis B virus gene during chronic infection in seven patients.

Journal of medical virology - 1 Jun 1994

Uchida T, Aye T T, Shikata T, Yano M, Yatsuhashi H, Koga M, Mima S

Abstract excerpt

We analyzed the evolution of the precore/core gene of hepatitis B virus (HBV) over a period of 6 to 11 years in seven patients with chronic HBV infection, who exhibited a variety of clinical features. Sequence analysis revealed the following results: (1) HBeAg to anti-HBe seroconversion was corre...

Topics

Adolescent
Adult
Amino Acid Sequence
Base Sequence
Chronic Disease
Female
Genes, Viral
Hepatitis B
Hepatitis B virus
Humans
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Sequence Analysis, DNA

Time Factors

Source

Identifiers

PMID: 8083662
DOI: 10.1002/jmv.1890430209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8083662-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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