Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of the hepatitis B virus gene during chronic infection in seven patients.

Journal of medical virology - 1 Jun 1994

Uchida T, Aye T T, Shikata T, Yano M, Yatsuhashi H, Koga M, Mima S

Abstract excerpt

We analyzed the evolution of the precore/core gene of hepatitis B virus (HBV) over a period of 6 to 11 years in seven patients with chronic HBV infection, who exhibited a variety of clinical features. Sequence analysis revealed the following results: (1) HBeAg to anti-HBe seroconversion was correlated roughly with the occurrence of precore-defective mutants, and several years appeared to be required for complete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Sequence Analysis, DNA

Share to Time Factors

Source

Identifiers

PMID: 8083662
DOI: 10.1002/jmv.1890430209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of the hepatitis B virus gene during chronic infection in seven patients.PMID 8083662Read ↗

Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection.Semantic proximity Read ↗

Naturally occurring hepatitis B virus core gene mutations.Semantic proximity Read ↗

Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis: implications of clustering changes in a small region of the HBV core region.Semantic proximity Read ↗

Evolution of precore/core promoter mutations in hepatitis B carriers with hepatitis B e antigen seroreversion.Semantic proximity Read ↗

Evolution of hepatitis B virus precore/basal core promoter gene in HBeAg-positive chronic hepatitis B patients receiving lamivudine therapy.Semantic proximity Read ↗

Comparison of envelope and precore/core variants of hepatitis B virus (HBV) during chronic HBV infection.Semantic proximity Read ↗

The natural history of chronic hepatitis B virus infection.Semantic proximity Read ↗

Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers.Semantic proximity Read ↗

Hepatitis may precede the occurrence of precore region mutation in hepatitis B virus genome during infection in young carriers.Semantic proximity Read ↗

Universal emergence of precore mutant hepatitis B virus along with seroconversion to anti-HBe irrespective of subsequent activity of chronic hepatitis B.Semantic proximity Read ↗

Precore mutant hepatitis B virus infection and liver disease.Semantic proximity Read ↗

Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.