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Article

A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.

Journal of bacteriology - 1 Sept 1994

Douglas C M, Marrinan J A, Li W, Kurtz M B

Abstract excerpt

A novel, potent, semisynthetic pneumocandin, L-733,560, was used to isolate a resistant mutant in Saccharomyces cerevisiae. This compound, like other pneumocandins and echinocandins, inhibits 1,3-beta-D-glucan synthase from Candida albicans (F.A. Bouffard, R.A. Zambias, J. F. Dropinski, J.M. Balkovec, M.L. Hammond, G.K. Abruzzo, K.F. Bartizal, J.A. Marrinan, M. B. Kurtz, D.C. McFadden, K.H. Nollstadt, M.A....

Topics

Anti-Bacterial Agents
Antifungal Agents
Cell Membrane
Chitin Synthase
Crosses, Genetic
Drug Resistance, Microbial
Farnesyl-Diphosphate Farnesyltransferase
Genes, Fungal
Glucosyltransferases
Kinetics
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsomes

Mutation

Peptides

Saccharomyces cerevisiae

Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8083161
DOI: 10.1128/jb.176.18.5686-5696.1994
PMCID: PMC196772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8083161-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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