Article
Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor.
G3 (Bethesda, Md.) - 8 Sept 2016
Rosenwald Anne G, Arora Gaurav, Ferrandino Rocco, Gerace Erica L, Mohammednetej Maedeh, Nosair Waseem, Rattila Shemona, Subic Amanda Zirzow, Rolfes Ronda
Abstract excerpt
Candida glabrata is an important human fungal pathogen whose incidence continues to rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat such infections are members of the echinocandin family, although there are increasing reports of resistance to these drugs as well. In efforts to better understand the genetic changes that lead to altered responses to echinocandins, we...
Topics
- Antifungal Agents
- Candida glabrata
- Candidiasis
- Caspofungin
- Cell Wall
- Drug Resistance, Fungal
- Echinocandins
- Humans
- Lipopeptides
- Microbial Sensitivity Tests
- Phenotype
- Saccharomyces cerevisiae