Article
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene.
Molecular & general genetics : MGG - 8 Jul 1994
Inokoshi J, Tomoda H, Hashimoto H, Watanabe A, Takeshima H, Omura S
Abstract excerpt
Cerulenin, an antifungal antibiotic produced by Cephalosporium caerulens, is a potent inhibitor of fatty acid synthase in various organisms, including Saccharomyces cerevisiae. The antibiotic inhibits the enzyme by binding covalently to the active center cysteine of the condensing enzyme domain....
Topics
- Amino Acid Sequence
- Base Sequence
- Cerulenin
- DNA, Fungal
- Drug Resistance, Microbial
- Fatty Acid Synthases
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Plasmids
- Saccharomyces cerevisiae