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Article

p53 mutations have no additional prognostic value over stage in bladder cancer.

British journal of cancer - 1 Sept 1994

Vet J A, Bringuier P P, Poddighe P J, Karthaus H F, Debruyne F M, Schalken J A

Abstract excerpt

Evidence is accumulating that the tumour-suppressor gene p53 is involved in the development of bladder cancer. Therefore we studied p53 mutations in 47 bladder cancers obtained from 45 patients using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. Eight out of 24 invasive tumours appeared to have a p53 mutation, while no p53 mutations were found in the superficial tumours....

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Identifiers

PMID: 8080737
DOI: 10.1038/bjc.1994.334
PMCID: PMC2033347

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