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Article

Pancreatic carcinomas of acinar and mixed acinar/ductal phenotypes in Ela-1-myc transgenic mice do not contain c-K-ras mutations.

The American journal of pathology - 1 Sept 1994

Schaeffer B K, Terhune P G, Longnecker D S

Abstract excerpt

c-K-ras is activated by mutation at codon 12 in the majority of human pancreatic carcinomas of ductal but not acinar phenotype. The Ela-1-myc transgene when expressed in transgenic mice induces pancreatic carcinomas of both acinar and mixed acinar/ductal phenotype. The histopathology of 110 pancreatic carcinomas were characterized in this model. A high percentage of the low to moderately differentiated acinar...

Topics

Animals
Base Sequence
Carcinoma, Acinar Cell
Carcinoma, Ductal, Breast
Genes, ras
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Neoplasms, Multiple Primary
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8080049
PMCID: PMC1890344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8080049-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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