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Article

Cycles, chaos, and evolution in virus cultures: a model of defective interfering particles.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 1994

Kirkwood T B, Bangham C R

Abstract excerpt

Defective interfering particles (DIP) are spontaneous deletion mutants of viruses that replicate at the expense of the parent virus. DIP have complex effects on the growth of viruses in vitro, including the establishment of persistent infection, cyclical variation in virus titer, eradication of replicating virus, and rapid evolution of the virus. We show here that a simple mathematical model, based only on...

Topics

Biological Evolution
Cells, Cultured
Defective Viruses
In Vitro Techniques
Models, Biological
Mutation
Viral Interference
Virus Replication
Viruses

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8078942
DOI: 10.1073/pnas.91.18.8685
PMCID: PMC44671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8078942-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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