Article
Stochastic model of vesicular stomatitis virus replication reveals mutational effects on virion production.
PLoS computational biology - 1 Feb 2024
King Connor R, Berezin Casey-Tyler, Peccoud Jean
Abstract excerpt
We present the first complete stochastic model of vesicular stomatitis virus (VSV) intracellular replication. Previous models developed to capture VSV's intracellular replication have either been ODE-based or have not represented the complete replicative cycle, limiting our ability to understand the impact of the stochastic nature of early cellular infections on virion production between cells and how these...
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