Consistent variation in amino-acid substitution rate, despite uniformity of mutation rate: protein evolution in mammals is not neutral.

doi:10.1093/oxfordjournals.molbev.a040142

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Article

Consistent variation in amino-acid substitution rate, despite uniformity of mutation rate: protein evolution in mammals is not neutral.

Molecular biology and evolution - 1 Jul 1994

Easteal S, Collet C

Abstract excerpt

Variation in mutation rate, attributed to differences in both generation time and in metabolic rate, has been invoked under the neutral theory of molecular evolution to account for differences in substitution rate among mammalian lineages. We show that substitution rates at fourfold-degenerate si...

Topics

Animals
Artiodactyla
Biological Evolution
Genes
Genetic Variation
Kinetics
Mammals
Marsupialia
Molecular Sequence Data
Mutation
Primates
Proteins
Rodentia
Sequence Alignment
Sequence Homology, Nucleic Acid

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