Article
Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular clock and the relationship of mammalian orders.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1991
Bulmer M, Wolfe K H, Sharp P M
Abstract excerpt
Synonymous substitution rates have been estimated for 58 genes compared among primates, artiodactyls, and rodents. Although silent sites might be expected to be neutral, there is substantial rate variation among genes within each lineage. Some of the rate variation is associated with G + C content: genes with intermediate G + C values have the highest rates. Nevertheless, considerable heterogeneity remains after...
Topics
- Animals
- Artiodactyla
- DNA
- Genes
- Mammals
- Models, Genetic
- Models, Statistical
- Mutation
- Nucleotides
- Phylogeny
- Primates
- Rodentia