Modulation of rhodamine 123 uptake by nigericin in sensitive and multidrug resistant leukemic cells.

doi:10.1016/0304-3835(94)90360-3

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Article

Modulation of rhodamine 123 uptake by nigericin in sensitive and multidrug resistant leukemic cells.

Cancer letters - 29 Aug 1994

Canitrot Y, Lautier D, Viallet P, Salmon J M

Abstract excerpt

We have investigated the effect of the ionophore nigericin (NIG) in multidrug resistant (MDR) cells, using intracellular accumulation of the fluorescent dye rhodamine 123 (R123). NIG increased the accumulation of R123 in half of the murine MDR RFLC3 population but not in the human MDR CEM/VLB 100...

Topics

Animals
Antimetabolites, Antineoplastic
Doxorubicin
Drug Interactions
Drug Resistance
Drug Screening Assays, Antitumor
Friend murine leukemia virus
Humans
Intracellular Membranes
Leukemia
Leukemia, Erythroblastic, Acute
Membrane Potentials
Mice
Mitochondria
Nigericin
Phenotype
Rhodamine 123
Rhodamines

Source

Open in PubMed

Identifiers

PMID: 8076364
DOI: 10.1016/0304-3835(94)90360-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8076364-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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