Article
Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Sept 1993
Rebay I, Fortini M E, Artavanis-Tsakonas S
Abstract excerpt
The Notch gene of Drosophila plays an important role in cell fate specification throughout development. The Notch protein contains a large extracellular domain of 36 EGF-like repeats as well as 3 Notch/lin-12 repeats and an intracellular domain with 6 cdc10/ankyrin repeats, motifs which are highl...
Topics
- Animals
- Cell Differentiation
- Drosophila
- Drosophila Proteins
- Gene Expression
- Genes, Dominant
- Insect Hormones
- Membrane Proteins
- Mutation
- Phenotype
- Receptors, Notch